Microsporidia: a promising vector control tool for residual malaria transmission
نویسندگان
چکیده
Long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) have resulted in a major decrease malaria transmission. However, it has become apparent that can be effectively transmitted despite high coverage of LLINs/IRS. Residual transmission occur due to Plasmodium -carrying Anopheles mosquitoes are insecticide resistant feeding resting behavior reduces their chance encountering the currently deployed control tools. is likely most significant hurdle achieving goal eradication research development towards new tools strategies therefore critical. One promising involves biological agents part mosquito microbiome influence ability transmit Plasmodium. These differ from previously used for vector primary effect on vectoral capacity rather than longevity fitness (which may or not affected). An example this type agent Microsporidia MB , which was identified field collected arabiensis caused complete inhibition falciparum without effecting host. belongs unique group rapidly adapting evolving intracellular parasites symbionts called microsporidia. In review we discuss general biology microsporidians inherent characteristics make some them particularly suitable control. We then priorities developing blocking strategy leading microsporidian candidate
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ژورنال
عنوان ژورنال: Frontiers in tropical diseases
سال: 2022
ISSN: ['2673-7515']
DOI: https://doi.org/10.3389/fitd.2022.957109